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Methyl carbamate : ウィキペディア英語版
Methyl carbamate

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Methyl carbamate (also called methylurethane, or urethylane) is an organic compound and the simplest ester of carbamic acid (H2NCO2H). It is a colourless solid.〔 Peter Jäger, Costin N. Rentzea and Heinz Kieczka "Carbamates and Carbamoyl Chlorides" in Ullmann's Encyclopedia of Industrial Chemistry, 2012, Wiley-VCH, Weinheim. 〕
Methyl carbamate is prepared by the reaction of methanol and urea:
:CO(NH2)2 + CH3OH → CH3OC(O)NH2 + NH3
It also forms in the reaction of ammonia with methyl chloroformate or dimethyl carbonate.
==Safety and occurrence==
Unlike its close relative ethyl carbamate it is not mutagenic in salmonella (it tested negative in the Ames test), but it is mutagenic in Drosophila.〔P. Foureman, J.M. Mason, R. Valencia and S. Zimmering, ''Environ. Mol. Mutagen.'', 1994, 23 (1), 51 - 63.〕 Experimental evidence does show that it is a carcinogen in rat, and not carcinogenic in mice. The compound is "known to the state of California to cause cancer" per Proposition 65.〔(OEHHA )〕

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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